Polynucleotides- Nucleofill Plenhyage and Plinest


Polynucleotides treatments like Plenhyage, Plinest & Nucleofill


Polynucleotide (PN) skin rejuvenation treatments have gained significant attention in aesthetic medicine. They involve a revolutionary, non-invasive procedure for enhancing skin texture and appearance. Based on utilising biological substances to stimulate tissue regeneration, PN treatments have emerged as a promising solution for individuals seeking to revitalise their skin without resorting to more invasive procedures.

What are Polynucleotides?

Polynucleotides are the building blocks of DNA molecules. They have been used since the 1950s for burn and wound healing and are known to possess bioactive properties that can aid in repairing and rejuvenating damaged skin.

They have been created synthetically or can be from animal origin. The most common products available for skin rejuvenation are extracted from salmon or trout sperm.  The DNA is purified so that patients with fish allergies are still suitable for treatment.

Nucleofill and Plenhyage are created from Salmon DNA fragments, and Plinest is made from Trout DNA fragments. 


How do Polynucleotides work?

When injected into the dermal layer of the skin, the PN DNA fragments act as signalling agents that stimulate fibroblasts and trigger the body’s natural regenerative processes, promoting cellular regeneration. This results in collagen and elastin synthesis and the production of essential structural proteins and hyaluronic acid, which improve hydration and moisture retention, restoring youthful skin characteristics.

As a result, patients may observe a reduction in the appearance of fine lines, wrinkles, and sagging skin. They also can create a healthier complexion and reduce the visibility of skin imperfections such as pigmentation irregularities and scars.

The gradual and cumulative effects of polynucleotide skin rejuvenation treatments make them a preferred option for individuals seeking gradual but noticeable improvements in their skin quality.


How long do the results of Polynucleotides last?

The results of PN treatments may generally last several months to a year. The average response lasts for six to nine months.

The duration of the effects of PN Treatments varies depending on the specific type of PN used, individual response to the treatment, and the initial condition of the skin. The longevity of their effects also depends on the body’s natural ageing process and environmental factors.


Which areas can Polynucleotides Treat?

PNs can revitalise the skin on all areas of the face and body.

  • Face: To improve facial skin’s texture, tone, and elasticity. They can help reduce the appearance of fine lines, wrinkles, and other signs of ageing, resulting in a more youthful and radiant complexion.
  • Neck and décolletage: The delicate skin on the neck and décolletage can also benefit from PN treatments, helping to tighten and firm the skin in these areas and reducing the appearance of lines and wrinkles.
  • Hands: PN therapy can be used to rejuvenate the skin on the hands, minimising the visible signs of ageing, such as thinning skin, wrinkles, and age spots, thereby improving the overall texture and appearance of the hands.
  • Body: PN treatments can also be applied to various areas of the body, such as the arms, abdomen, and thighs, to promote skin regeneration, improve elasticity, and reduce the appearance of cellulite and stretch marks.
  • Scalp: In recent years, PN treatments have gained attention for their potential to promote hair growth and improve scalp health. When administered to the scalp, PN therapy can help strengthen hair follicles and stimulate hair growth, contributing to thicker and healthier-looking hair.

How many Treatments will I need?

Most people require three treatment sessions in total.

We recommend one session (2ml) every 14- 21 days.


Contraindications to Polynucleotide Treatment

  • Pregnancy
  • Breast Feeding
  • Active skin infections

Patients with the following conditions can sometimes be treated with caution:

  • Blood Thinning Medication
  • Autoimmune conditions

What side effects can I expect after a PolyNucleotide Skin Rejuvenation Treatment?

During treatment, you will experience pin-prick bleeding and sometimes itchiness.

For several days, you can expect the following in the treatment area:

  • redness
  • slight swelling
  • Bruising

Occasionally, the bruising and swelling can last longer.


After Care

  • Avoid touching the treated area for at least 12 hours
  • Avoid Makeup for 24hrs
  • Avoid direct sun exposure
  • SPF to protect the area and prevent further skin ageing.
  • No facial treatments for two weeks

Who Performs Polynucleotide Treatments at Cheshire Lasers?

The following Doctors and Nurses perform Polynucleotide treatments at Cheshire Lasers:


In Conclusion

Polynucleotide skin rejuvenation treatments represent a breakthrough in the field of aesthetic medicine, offering a safe and effective solution for individuals looking to revitalise their skin’s youthful characteristics. By harnessing the regenerative potential of PN molecules, these treatments stimulate collagen synthesis, enhance skin hydration, and promote overall skin health, leading to a more radiant and youthful complexion. As the field of aesthetic medicine continues to evolve, polynucleotide skin rejuvenation is poised to remain a prominent player in the quest for achieving natural and long-lasting skin rejuvenation.


 

HArmonyCa

HArmonyCa information Cheshire

What is HArmonyCa™?

HArmonyCa is a dual-effect Hybrid Injectable. It contains two active ingredients, calcium hydroxyapatite (CaHA) and hyaluronic acid (HA). These two components are in well-known dermal fillers and have both been in use for over two decades.

It also contains lidocaine, an anaesthetic, to reduce the discomfort of treatment.

How do HA and CaHA work?

Hyaluronic acid has a volumising, lifting and hydration effect. The results are immediate and can last anything from 3 to 18 months.

Calcium hydroxyapatite has an excellent collagen stimulation effect which causes skin firming and tightening. Over time the particles stimulate the production of a collagen network in the skin, creating a tightening and lifting effect that can last 1-3 years. 

Which areas can HArmonyCa treat?

HArmonyCa works best under the surface of the skin where collagen stimulation is needed. It cannot be injected around the eyes, lips or mouth.

What makes HArmonyCa different from other Biostimulators?


Biostimulators work differently, and the results and longevity vary from person to person. What makes HarmonyCA even more different is that it is the first one to combine a biostimulator with hyaluronic acid.  


HArmonyCa Cheshire


HArmonyCa Aftercare

  • You should avoid strenuous activity and exposure to sunlight and tanning lamps or extreme weather conditions for 24 hours post-treatment in order to reduce redness, swelling and irritation.
  • Massage the area morning and night for seven days to reduce the incidence of nodules.
  • If nodules (small lumps and bumps under the skin) appear, you should massage the treated area, and if they do not go in a day or two, please contact us for an urgent review.
  • Redness, swelling, itching, discomfort and tenderness are common after treatment and usually settle within 24–48 hours.

ALWAYS PROMPTLY report the following to us:

  • Any adverse event which doesn’t resolve within the typical time frame
  • Any adverse event which worsens,
  • Any other adverse event

Less common adverse effects include:

  • bruising
  • prolonged swelling
  • fluid under the skin
  • longer lasting nodules
  • extrusion (misshaping due to force)

Rare side effects include:

  • infection
  • induration (hardening)
  • skin pigmentation,
  • inflammatory reaction
  • allergic reaction
  • migration
  • persistent nodules (small bumps)
  • granulomas (small area of inflammation)
  • necrosis (cell death)
  • blindness

HArmonyCa Cheshire


Who Performs HArmonyCa Treatments at Cheshire Lasers?

The Following specialists performs HArmonyCa treatments at Cheshire Lasers.

Dr Teri Johnson – view her prices here.

Dr Kyra Drinnan – View her prices here


 

Semi Permanent Makeup Removal


laser semi permanent eyebrow removal


How do you Remove Semi Permanent Makeup and Microbladed EyeBrows?

At Cheshire Lasers, we use our Lynton Lumina Q Switched laser to remove semi-permanent makeup eyebrows and micro-bladed eyebrows. This is the same machine we use for removing conventional tattoos. Unfortunately, it is not possible to remove eyeliner or lip liner this way.


Can you Correct an Area Instead of Removing the Entire Brow?

Depending on your concern, we can treat small areas to correct your eyebrows, or we can treat the whole eyebrow.


How does Laser Semi Permanent Makeup Removal Work?

The laser cracks the semi-permanent makeup pigment tattooed into the skin to create smaller pigment particles. The body then breaks down these smaller particles and removes them slowly over time.


How often will I need Treatment?

We normally recommend a treatment every 6 -12 weeks. This depends on how quickly you want it to fade.


How Many Treatment Sessions Will I Need?

Most people need between 3-6 treatments. This will depend on whether you want the pigment to fade or go completely.


Unwanted Effects from Laser Semi Permanent Makeup Treatment?

The commonest unwanted reactions often seen after laser treatment of semi-permanent make-up are:

  • eyebrow hair reduction
  • a change in the colour of brow pigment

Approximately 10% of the eyebrow hairs can be destroyed due to the laser treatment. Although we move these hairs out of the way during the removal process to prevent this as much as possible. In most cases, these hairs grow back, but the outcome varies from person to person.  Eyebrow hairs can also temporarily go paler, but you can tint these a week after the treatment.

The laser oxidises the pigment in the skin during treatment; when this occurs the pigmentation can change colour. Depending on the pigment, it can go darker in colour, or the colour can change to an orangey/rusty colour. Once the pigment is oxidised it can then be treated in subsequent treatment.


What Will My Brows Look Like After Treatment?

You may see frosting and whitening of the pigment immediately after treatment, it is also common to see some pinpoint bleeding and some swelling. The reaction usually settles after 1-2 weeks.


How long Before I can Have Further Semi Permanent Makeup?

After laser treatment, we recommend you wait 8-12 weeks before commencing treatment.

Please ask us the exact time we recommend you wait as this will depend on many factors.


How Much is Laser Treatment of Semi Permanent Makeup?

You can view all our Laser Prices here


View our Before And After Images of Laser Semi Permanent Makeup Removal

 

Before and after one treatment

before and after tattoo brow removal

Before and after two treatments  and then four treatments (also had brow hair tint)

laser eyebrow treatments Cheshire


 

RadioFrequency RF Microneedling


Dermaforce microneedling


At Cheshire Lasers, we use Dermaforce to deliver RadioFrequency (RF) Microneedling. This advanced treatment combines microneedling with Radiofrequency (RF) technology to effectively treat a large number of cosmetic concerns, with excellent results.

This combination treatment has become more and more popular recently due to improvements in the way the technology is used to deliver better results. It is also more popular due to its extensive coverage on social media and in the press.


How RadioFrequency Microneedling Works

Insulated fine gold-plated needles deliver Bi-Polar Radio Frequency (RF)  into the skin. The depth of the treatment varies depending on the skin concerns that need treating. The radiofrequency energy heats the tissue in the region of 55 – 65°C and, depending on the depth, will stimulate cell renewal, new collagen, increased hydration and resurfacing.

how RadioFrequency Microneedling Works

how radiofrequency microneedling works


How is New Collagen Stimulated?

The energy/heat released into the skin causes immediate trauma to the existing mature, dehydrated collagen cells causing contraction and damage to this tissue. This damage stimulates a fibroblast action (fibroblasts are the connective tissue cells that produce collagen and elastin) which results in the production of new collagen and an increase in the diameter of the collagen fibres. The spaces between the fibres are also reduced.

This result causes an increased density of the dermal layer giving a skin-tightening effect.


What Can RadioFrequency Microneedling Treat?

  • Loose and Sagging Skin
  • Fine Lines and Wrinkles
  • Pitted Skin
  • Uneven skin texture
  • Stretch Marks

Which areas can it treat?

We usually recommend a full-face treatment rather than treating specific facial areas. However, we can focus more on specific areas if they need more improvement.

Areas that RF Microneedling work well on include:

  • Crows feet
  • Neck and décolletage
  • Perioral/ Mouth area
  • Jowls and jawline
  • Large pores
  • Scaring

RF Microneedling can also treat areas on the body, including hands, arms, knees and abdomen.


Before and after RF Microneedling

before and after RF microneedling treatment

After one treatment at Cheshire Lasers. before and after RadioFrequency Microneedling

Before and after supplied by the manufacturer


Contraindications to RF Microneedling

  • Pregnancy, recent pregnancy or breastfeeding
  • Pacemakers
  • Metal Implants near the treatment area ( within 2.5cm ) Exclude fillings and most dental work.
  • Infected or inflamed skin
  • Any active infection
  • Uncontrolled Diabetes and Epilepsy
  • Some Auto-Immune Conditions
  • Active Cancer
  • Keloid Scarring (historical or current)
  • Skin Thinning Medication, including Roaccutane Steroid Medication
  • Anticoagulant Medication
  • Selected Immunosuppressants
  • Hernia or Mesh near the treatment area

If you have a history of cold sores, you must discuss this at your consultation.


Intervals Between Other Treatments.

For the following cosmetic procedures, allow a two weeks window before and after treatment:

  • Botox
  • Superficial Peels
  • Microdermabrasion
  • IPL / Laser

If you have had the following procedures in the treatment area in the last 18 months, you will require a medical assessment to assess your suitability:

  • Dermal Fillers
  • Sculptra
  • Skin Boosters
  • Threads

If it is in a different area, treatment can be commenced 2-8 weeks later, depending on your assesment.

  • Retinol product and Prescription Vitamin A treatments stop three days before treatment and restart at least three days after or once the skin has fully recovered.

What is a RF Microneedling Treatment Like?

The treatment can be uncomfortable due to the needling and the heat generated. We can reduce the discomfort by applying anaesthetic cream before your treatment.

During the treatment, your skin will go red and will start to feel warm, like sunburn.

during a RF microneedling treatment

During Treatment

 

skin appearance after an RF microneedling treatemnt

Shortly after Treatment

 

You will see red squares on your skin due to heat energy and the vacuum in the handpiece. These squares usually go in a few hours, but sometimes it can take a few days for them all to go from the face, and even longer after body treatments.

  • Up to 24 hours: you will possibly experience erythema and mild swelling.
  •  2–3 days: reduced erythema and minor skin dryness and flaking.
  • 3–4 days: potential dryness.
  • 4–5 days: full recovery.
  • 4–6 weeks: improvement in collagen health visible.

Side Effects after RF Microneedling

Expected side Effects Include:

  • Redness for up to 24 hours
  • Mild Swelling up to 24hrs
  • Dryness and Flaking for around three days

Complete recovery usually occurs 3 to 5 days after treatment.

Less Common Side Effects Include:

  • Bruising
  • Prolonged redness or red patches for several days
  • Prolonged dryness and flakiness for a week

Please contact us if you experience any other side effects after your treatment,


Pre Treatment Advice:

  • Stop using ‘active’ skincare three days before treatment (ie. AHA, BHA, Retinol (Vitamin A)).
  • Avoid direct sun exposure before and after treatment.
  • Excessive facial hair, beards and moustaches need to be clean-shaven prior to treatment.
  • Avoid the use of aftershaves and perfumes on the treatment area.

Post Treatment Care

  • Avoid direct sunlight for 24 hours, and no sunbeds during your Dermaforce course.
  • Do not apply spray tan or self-tan for 2–3 weeks post-treatment.
  • Use SPF 50 sunscreen.
  • Avoid touching the skin directly after treatment.
  • Keep skin dry for 24 hours and avoid scratching
  • Avoid active skincare for 3–5 days after treatment.
  • No swimming for 24 hours
  • No exercise or strenuous activity that will cause sweating until the skin has recovered.

Post Treatment Suggestions

  • Use a clean pillowcase.
  • Use hydrating and anti-inflammatory skincare.
  • Avoid non-mineral makeup for 24 hours.
  • Avoid swimming, hot tubs, saunas and active exercise for 48 hours.
  • Consider the environment. Hot, humid conditions can contribute to excess inflammation.
  • Avoid shaving area for 24–48 hours
  • Do not allow pets to lick the skin
  • Face masks should be disposed of and not reused.
  • Do not pick flaky skin.
  • Drink plenty of water

RadioFrequency Microneedling Prices


Book a consultation

Book a consultation here.


Lip Treatments

Lip Dermal Filler, Lip Flick with Botox Cheshire Middlewich

Lip Dermal Filler, Lip Flip with Botox Cheshire Middlewich


Dr Teri Johnson discusses the wide range of treatments for the lips and the area around the mouth at Cheshire Lasers. The treatments involve the use of Dermal Fillers, Botox, Polynucleotides as well as other rejuvenation treatments to achieve the following goals:

  • Lip Enhancement
  • Lip Rejuvenation/ Restoration
  • Lip Hydration
  • Lip Line Treatments
  • Lip Flip

Lip Enhancement

A lip enhancement treatment plumps the lips, replaces lost volume and improves lip hydration. Dermal Fillers are the best treatment for this.

The following specialists provide Lip enhancemnet with Drermal Fiilers at Cheshire Lasers:

Find out more about Lip Enhancement here.

Before and After Lip Enhancement Treatments

Images provided by Aesthetic Nurse Katey Moulton

Before and After Lip Enhancement with Dermal Fillers by Katey Moulton

Before and After Lip Enhancement with Dermal Fillers by Katey Moulton

Before and After Lip Enhancement with Dermal Fillers by Katey Moulton

before and after lip dermal filler Middlewich Cheshire

Belotero Lip enhancement Middlewich Cheshire

Belotero Lip enhancement Middlewich Cheshire

Belotero Lip enhancement Middlewich Cheshire


Lip Rejuvenation / Restoration

There are many treatments available for Lip Rejuvenation at Cheshire Lasers. Dermal Fillers are also successful for this treatment; a soft subtle dermal filler around the lip area recreates a youthful appearance, adds back hydration, and can significantly reduce fine lines.

Lip Rejuvenation with Dermal Filler is available at Cheshire Lasers with the following specialists:

Aesthetic Nurse Moira uses Belotero Balance which is excellent for improving even the finest likes around the Mouth. Dr Johnson uses Juvederm and Restylane dermal fillers. Katey uses Restylane and Dr Drinnan uses Juvederm.

Find out more about Lip Rejuvenation here.

Before and After Lip Rejuvenation

Images provided by Dr Teri Johnson

Before and After Lip Rejuvenation by Dr Teri Johnson

Before and After Lip Rejuvenation by Dr Teri Johnson Dr Teri Johnson Middlewich Cheshire

Before and After Lip Rejuvenation by Dr Teri Johnson Dr Teri Johnson Middlewich Cheshire

The following images are provided by Aesthetic Nurse Moira.

She uses Beletero Balance in her patients to soften the lip lines and rejuvenate the area about the mouth. Moira uses a special blanching technique to decrease the lines but not increase the volume of the area.

Belotero Balance to Soften Lip Lines Middlewich Cheshire


Botox Treatments

Botox can be used around the mouth to offer two types of results:

Smoker’s Line Reduction

Botulinum Toxin relaxes the muscles that purse the lips. By reducing the repeated contractions, the fine lines caused by the movement reduce for about 8 to 10 weeks.
This treatment takes knowledge and skill, as too much muscle relaxation can lead to weakness of the mouth muscles.

The Lip Flip

The Lip Flip is when botox injections around the mouth muscle at certain points relax the lip muscle and ‘flips’ the lip out to make it appear fuller, plumper and much more visible.

Find out more about Botox Treatments in general here.

Botox treatments around the mouth are provided by Dr Teri Johnson, Moira Grobiki and Dr Kyra Drinana.


Lip Line Treatments

If you would like to treat your lip lines only, you can view more details about how we treat them here. 


Alternative Lip Rejuvenation Treatments

We can improve around the mouth with a variety of other treatments.

Effective Perioral Lip Rejuvenation Treatments Include:


How do I arrange a Lip Treatment?

We recommend you always have a consultation first.

Decide who you prefer to see and arrange a consultation online or by phone.

Alternatively, complete this form and we will contact you to discuss who would be the best person for you to see.


Injectable Skin Booster Treatments

skin booster profhilo Nucleofill sunekos Cheshire

skin booster profhilo Nucleofill sunekos Cheshire


What Are Skin Booster Treatments?

” Skin Booster” describes a range of Injectable Skin Rejuvenation Treatments.

The first Skin Boosters were made from hyaluronic acid gel, similar to dermal fillers. The gel was injected into the top layers of the skin to produce skin hydration and plumping.

Sometime later, more advanced products became available that did not just plump and hydrate the skin but also had an additional action on the skin cells. These new products stimulate the cells of the skin in a range of different ways, so they don’t just hydrate the skin but also stimulate the production of collagen and elastin.

These treatments perform a process of bio-remodelling, and all of them require a course of treatments a number of weeks apart.


Which Skin Booster Treatment is Best for me?

There are so many available now it is difficult to know which one is best for you. At Cheshire Lasers, we have tried so many over the years. Some we continue to use, and others we have discontinued when something better has come along.

Each treatment contains different ingredients with different properties and also different modes of action.
The procedure for delivering the treatments to the skin also varies. Some require needle injections, whereas others require a cannula to place the product into the skin. The downtime after each treatment and the common side effects post-treatment also vary.

There are pros and cons to each type. It depends on the area of concern, which treatments you have had before and how you have responded. Do you prefer a needle or cannula treatment? Or prefer to have fewer treatment sessions?  Or prefer a treatment which does not contain hyaluronic acid?

Collagen stimulation is not an exact science, and some people respond to one treatment better than another.


At Cheshire Lasers, the following Skin Boosters are available:


Profhiloprofhilo treatment cheshire

Profhilo has been one of the most popular skin booster treatments at Cheshire Lasers.

This treatment has been available since 2017 at Cheshire Lasers, so our medical team have lots of experience with this treatment.

Active ingredients:  Hyaluronic acid.

💉💉 It involves ten injection points which result in small lumps under the skin.

The treatment takes 5 to 10 minutes.

The lumps go down over 8-24 hours as the product disperses under the skin.

The treatment promotes collagen and elastin growth to reduce skin laxity and improve skin hydration.

Most people need two treatments one month apart.

Results last for approximately six months.

To maintain results, you will require a maintenance treatment every 4-6 months.

This treatment is performed by Dr Teri Johnson, Aesthetic Nurse Moira Grobicki and Dr Kyra Drinnan.


Polynucleotides

Polynucleotides- Nucleofill Plenhyage and Plinest Rejuvenation TreatmentsPolynucleotides have been used since the 1950s; initially, they were used for wound healing.

Active ingredients: Polynucleotides ( the building blocks of DNA).

Nucleofill, Plenhyage, and Plinest are all polynucleotide treatments that regenerate the skin by stimulating collagen and elastin growth in the skin. They also improve signs of ageing, reduce laxity and dehydration, and improve scars and some pigmentation.

Polynucleotides can improve the skin anywhere. They are a popular treatment for the tear trough area, where they help decrease lower eyelid laxity, fine lines, and wrinkles and improve skin hydration.

💉💉  It involves multiple injections into the skin with a needle or cannula.

Side effects include bruising and swelling for a few days.

The treatment stimulates fibroblasts to create collagen and elastin; it also stimulates hydration and has an antioxidant effect.

Most people require two to three treatments, two to three weeks apart.

You will need another treatment every three to six months to maintain results. (Frequency depends on your response to treatment.)

Find out more about Polynucleotides here: 

This treatment is performed by Dr Kyra Drinnan,  Dr Johnson, Dr Hazlehurst and Aesthetic Nurse Moira Grobicki.


Light Eyes Ultra

light eyes ultra CheshireLight Eyes Ultra has been around in the UK since 2020.

It contains a cocktail of hyaluronic acid, antioxidants, and botanical extracts formulated for the delicate eye area.

💉💉   The treatment involves multiple injections with a very fine needle tip.

Side effects include minimal swelling, redness and bruising, which usually subside over a few days.

It helps to brighten, firm, and refresh the area around the eyes.

This treatment is most suited for under-eye dark circles.

Most people require four treatments, two weeks apart.

This treatment is performed by Aesthetic Nurse Moira Grobicki and Dr Kyra Drinnan.


PRP

PRP has been around a long time.

It is a natural skin booster treatment that uses the platelets from your own blood.

When activated, platelets secrete and release at least seven different growth factors which enhance the natural healing processes.

💉💉💉The treatment involves multiple injections with a fine needle.

PRP can treat all the layers of the skin, superficial and deep.

The treatment stimulates collagen growth, improves the blood supply to the tissues and can greatly improve skin tone and texture. It also reduces fine lines and wrinkles.

Most people require three or four treatments, one month apart.

PRP is performed by Aesthetic Nurse Moira Grobicki.


Sunekos

sunekos CheshireSunekos has been around since 2020.

Active ingredients:  Hyaluronic acid and Amino Acids.

💉💉💉💉It involves multiple injection points.

It involves injecting two different products; one is for deep hydration, and the other goes more superficially into the skin.

Sunekos stimulates the fibroblasts in the skin to produce collagen and elastin.

It helps improve skin ageing, skin dryness, acne scarring, sun damage, loss of tone & elasticity, under-eye dark circles and fine lines and wrinkles.

Sunekos can treat the face, neck, décolleté, forehead and hands. It is particularly effective in the Periocular (eye) area, to reduce fine lines, dark circles and bags.

Most people require four treatments, 7-12 days apart.

You will require a maintenance treatment every 3-6 months to maintain results.

Sunekos is performed by Aesthetic Nurse Moira Grobicki.


 

Cysteamine Cream for Pigmentation


Senté Cysteamine Cyspera Cream DermaQuest MelaQuest Cysteamine Serum


What is Cysteamine Cream?

Cysteamine cream is a skin-lightening agent known for treating hyperpigmentation disorders such as age spots, melasma and post-inflammatory hyperpigmentation. Dermatologists have been recommending it for several years since it has been available in the UK. 

Cyspera Cysteamine Cream was the first brand available in 2019, and it became popular due to published evidence supporting its effectiveness. A few years later, it was discontinued and replaced by Cyspera Intensive which has also been discontinued in the UK.

In 2023, Santé created an alternative version, Senté Cysteamine HSA Pigment & Tone Corrector.

In 2024, Dermaquest launched their Cysteamine products DermaQuest MelaQuest Cysteamine Serum and DermaQuest MelaQuest Cream with Cysteamine these products are different to the original products as they can be left on the skin and no not need to be washed off.


What is the difference between Dermaquest Cystamine Serum and Cream, Cyspera and Cysteamine HSA

The original Cyspera contained 5% Cysteamine cream and came in a 50g tube. Cyspera Intensive, contained 7% Cysteamine cream with added ingredients such as AHAs to enhance pigmentation reduction, Isobionic-Amide, which is an anti-inflammatory B3 derivative and other ingredients to mask the smell slightly because the ingredients could not be combined in the tube it comes in a 30ml dual pump. This product has been discontinued in the UK. These were both mask treatments which needed to be washed off after 15 minutes.

Senté Cysteamine HSA Pigment & Tone Corrector contains 5% Cysteamine Cream in a 50ml tube. It also contains B3 niacinamide and HSA, which in combination improve skin tone by treating pigmentation and reducing redness or inflammation. Senté Cysteamine HSA Pigment & Tone Corrector should be applied like a mask on the problem area and washed off after 15minutes.

DermaQuest MelaQuest Cysteamine Serum and DermaQuest MelaQuest Cream with Cysteamine also contain antioxidants- Glutathione and Ginko Biloba to reduce inflammation and skin sensitivity, a tyrosine inhibitor – Kojic Acid to help reduce pigmentation and Snow Algae, which improves the skin’s collagen and cellular defence.

DermaQuest MelaQuest Cysteamine Serum contains 4% Cysteamine, which is shown to be as effective as prescription 4% hydroquinone and DermaQuest MelaQuest Cream with Cysteamine contains 3% Cysteamine. Both of these products can be left on the skin, which makes your daily routine easier. They still have an aroma, but this is masked by some of the other ingredients. For best results, Dermaquest advises you to use the serum and then the cream twice daily.
Some people may try the serum first on its own and add on the cream if the would like to enhance the results.


Skin Sensitivity with the Different Cysteamine Creams

Cysteamine is known for causing irritation for some users, hence why the latest versions contain ingredients to counteract this.

Sante, however, uses their HSA compound to provide a soothing repair base to the Cysteamine cream, so it is more suitable for sensitive skin and red skin.

Dermaquest uses glutathione and Ginko Biloba to reduce inflammation and skin sensitivity,


How to use the different Cysteamine Creams

For all products: If you have never used it, begin with a patch test. Then, apply every other day to the treatment area and increase to everyday use as tolerated.

For Cyspera and Sente products:

  • Do not wash the skin before application.
  • If necessary to wash, you must wait for one hour before applying Cyspera and 20 minutes before applying Senté Cysteamine HSA Pigment & Tone Corrector
  • Apply a thin layer on the pigmented skin you wish to treat
  • Leave on for 15 minutes
  • Remove by washing the area with a gentle face cleanser.
  • Gently pat your face dry and apply a gentle moisturiser and SPF if in the day

Do not leave on for more than 15 minutes.

  • Intensive phase: Once per day for up to 16 weeks.
  • Maintenance phase: Twice-weekly, once per day, indefinitely.
  • Use a high SPF sunblock to prevent activating the pigmentation.

For Dermaquest Serum and Cream:

For best results, you need to make sure you are consistent and apply products daily.


How does it Cysteamine work?

As the name implies, the cream contains cysteamine, a metabolite of L-cysteine and a natural cellular component. L-cysteamine inhibits the production of melanin in the skin in several different ways, which is why it is so effective.

It works as an Antioxidant and also inhibits the Tyrosinase enzyme, reducing the production of melanin precursors, therefore decreasing pigment production.

There is a randomised, double-blind, placebo-controlled clinical trial that confirmed the efficacy of cysteamine cream in the treatment of epidermal melasma.

A reduction in pigmentation is usually seen after six weeks of consistent use. It takes 8 to 16 weeks of regular use to achieve optimal results

Find out more about other pigmentation treatments at Cheshire Lasers here. 


If you have not used Cysteamine Cream before and want to purchase it. You are welcome to arrange a consultation to advise you on how to use the products and how to add them to your routine.

Cysteamine Cream Consultation form.


Cysteamine Cream Special Offer

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Under Eye Wrinkle Treatments


under eye wrinkle treatments cheshire


Cheshire Lasers Shares Their Quest to Improve Under Eye Wrinkles:

Cheshire Lasers keeps investing in the latest under-eye treatments.  Improving this area is challenging, and the results can be disappointing. We have so many successful solutions for treating or improving other areas of the face. However, the under-eye area has a different story.

Over the years, Cheshire Lasers has invested in numerous treatments and machines, hoping to find the latest best treatment for under-eye wrinkles. Sadly, many of them have not fully met our expectations. The treatments either don’t deliver consistently high-quality results in everyone, or they cause too much downtime or discomfort. This does not mean they do not work, because they do, but the results don’t work well in everyone or don’t meet the client’s expectations.

The more aggressive treatments work the best, but some of them can leave you bruised for a week or more, especially when a course of treatments are required.


Which treatments can improve under-eye wrinkles?

Cheshire Lasers offers all of the following Under Eye Treatments.

Our favourite treatments for this area at the moment are Nucleofill, PRP,  CACI Eye ReviveUltraformer MF2 and RF Microneedling

Injectable Treatments:

Botox for Dynamic Wrinkles

Most people have heard of Botox; it is excellent for treating what they call dynamic wrinkles, which are wrinkles caused by repetitive muscle movement. Botox works by temporarily paralysing the muscles that create your wrinkles and fine lines. Treatment of these muscles causes the muscles to relax and the wrinkles soften.

Botox is very effective at muscle relaxation (it starts working within a few days), and as long as you do your research and go to a recommended experienced medical practitioner, you won’t end up with the ‘frozen face’ you see in some celebrities.

Botox helps with dynamic wrinkles, commonly known as crow’s feet, but it does not work so well if your concern is directly under the eye. This is because these lines are usually due to loss of collagen and elasticity of the skin and not just repetitive movement.

Find out more about Botox here. 


Injectables That Stimulate Collagen Production.

Cheshire Lasers offers a wide range of injectable treatments that stimulate collagen in the skin to improve skin texture and elasticity under the eyes. They can also help improve puffiness and dark circles and are now more popular than tear-trough injections.

They all involve a course of treatments and can deliver fantastic results.  We also still provide tear trough treatments but these are only suitable for certain patients depending on their problem.

View all our under-eye injectable treatments here. 


Treatments For Under Eye Wrinkles Non-Injectable:

Most other under-eye anti-ageing treatments involve damaging your skin to make it heal, repair and then regenerate. The results last for varying lengths of time. Generally, the more aggressive the treatment, the better the results and the longer they last.

There are various ways to damage the skin surface:

Some downtime:

Slight downtime:

No Downtime


Treatments unlikely to cause downtime:

Ultraformer MF2

Ultraformer MF2 causes injuries just under the skin using ultrasound energy. The high-intensity energy can be focused at the depth we want, causing injury to the collagen. It does not damage the visible upper layer of skin cells known as the epidermis, so there is little downtime.
This treatment could cause some bruising if you are unlucky. It can also cause a bit of redness, which usually goes after an hour or two. Sometimes it can cause slight swelling, which generally lasts hours or a few days if you are unlucky. Ultraformer MF2 usually requires a course of 3 treatments, sometimes more. It is currently the most popular treatment at Cheshire Lasers. The results are typically visible one month after your first treatment, but the result of collagen remodelling, tighter, younger-looking skin can take three months to be fully appreciated.

Generating approximately 65.4°C into target layers induces natural coagulation and wound-healing processes to stimulate collagen renewal underneath the epidermis. You can read the scientific explanation about how this treatment works here. 

 

ultraformer mf2 eye treatment

 


Radiofrequency Treatments

The ThermaClinic eye treatment, the Endymed eye treatment, uses radiofrequency technology to heat the skin to around 40 degrees Celsius, which is about the same temperature as a hot shower. The collagen in the dermis layer of the skin is heated to a level where it will contract. This brings on healing and repair, producing new collagen, which remodels and tightens naturally over time.

under eye wrinkle treatment radiofrequency

 


The CACI Eye Revive

The CACI Eye Revive Treatment involves low-level radiofrequency technology to stimulate collagen, and it then opens up the skin channels of the skin to encourage penetration of hydrating products from the eye revive mask. It soothes tired, puffy eyes, reduces dark circles, lifts hooded eyes and yes, reduces fine lines and wrinkles.

A one-off treatment can lead you to a refreshed look and is great before a special event. However, a course of treatments delivers the best results.

Before and after caci eye revive


Treatments causing surface trauma and downtime:

RadioFrequency Microneedling

Radiofrequency Microneedling involves puncturing tiny holes into your skin which then delivers an electric current to the collagen layer. This energy damages the skin  and underlying collagen to create newer, younger looking firmer skin. The procedure is performed under local anaesthetic, so it is only moderately irritating, despite how it sounds.
The cons: It takes 4-24hrs for the redness to settle. 3 treatments every 5 weeks may be needed for best results, which include brightening, smoothing and fine-line reduction. Although you can take things slowly and have a treatment every few months.

Laser

Resurfacing lasers create trauma to your skin. The most popular one is a CO2 laser. This is often fractionated in small dots to reduce the amount of trauma to the skin and the downtime. There are some downsides to Laser treatments. Your skin will look and feel badly sunburned for a few days to a couple of weeks depending on the intensity of the treatment. It then goes sandpapery texture for a week or two. The results can be fantastic as long as you are prepared for the downtime. No pain no gain as they say! This treatment is not currently available at Cheshire Lasers. Why not visit The Consulting Room website to see who provides this treatment near you.

Plasma

Plasma Devices use Plasma Energy to create trauma to your skin. The downside is the immediate side effects including, swelling and reddening over the treated area for at least 2-3 days. The healing process will include crusting (which should be left to fall away naturally) over the course of about 7-10 days. Sometimes you can be left with residual inflammation/redness of the skin for weeks after treatment. This treatment is, therefore, more popular for the upper eye area where it can be covered rather than under the eye.
Find out more about Plasma here. 


How do I know which under-eye rejuvenation treatment is for me?

Injectable treatments run the risk of bruising and swelling after each treatment. Some of the treatments can help the under-eye dark circles as well as the fine lines.

The more ablative treatments such as CO2 laser and Plasma may require fewer treatments but have a longer downtime and can be more uncomfortable.

The Ultraformer is a compromise as it is quite aggressive in the deep layers of the skin. However, it rarely causes downtime. It can be uncomfortable, but the treatment is quick to perform, so any discomfort is over quickly.

CACI Eye Revive is a very relaxing, enjoyable treatment, but a course of 10 treatments is required once or twice a week.

RF Microneedling is an excellent treatment with excellent results and very little down time. However due to the cost of  the disposable equipment, it is more expensive to perform and is only cost effective if you are considering a full face or face and neck procedure.

Radiofrequency is also a more enjoyable treatment which feels a bit like a hot stone massage for the face.  Maintenance is recommended every six weeks after an initial course of 6 to 8 treatments.

If you are not ready for any of the above treatments, you could try under-eye products. 


Please let us know if you would like a consultation for us to discuss your options.


You can book a consultation to discuss our non-injectable treatments here.


Why do we get under-eye wrinkles?

As we age, we lose collagen and elastin in the skin, so the skin loses its capability to bounce back when we move and make different facial expressions. Facial expressions are important, but they do put a strain on our skin and its supporting collagen and over time, can cause dynamic wrinkles.

Smoking, sun exposure, diet and genetics also influence how the skin ages.

One study shows that smoking 30 cigarettes daily will add 14 years to your skin!

There are two types of UV rays present in sunlight. UVB, which is responsible for giving you sunburn and UVA. It is the UVA rays that are responsible for DNA damage and ageing of the skin.

Sugar may also contribute to premature ageing through the process of glycation. Glycation can cause damage the skin tissues over time and may make you more prone to having fine lines and wrinkles.

Genetics and our DNA can also play a role in ageing. Often if your parents and grandparents have great skin, you will, too. However, if they have skin issues like big pores and acne-prone skin, you may also be more susceptible to these issues.


How to prevent wrinkles?

Avoiding smoking, limiting sun exposure and cutting down on sugar will all help to improve your skin health. Eating a healthy, well-balanced diet rich in fruits and vegetables and including oily fish, like salmon, will also improve your skin health. Vitamins and minerals from fruits and vegetables will boost your overall health and give you a glow from within. Hydration is also crucial to keeping your skin healthy and clear, so ensure you are getting enough water throughout the day, too.

Some serums and creams are designed for the eye area that can help prevent more wrinkles.

The ingredients to look out for are:

  • Retinol.
  • Antioxidants
  • Patented peptides.
  • AHAs
  • Hyaluronic acid / B5 serum

Find out about these ingredients, how they work, and what products you can find them in here. 


 

pHformula Skin Resurfacing


pHformulaThe pHformula Skin Resurfacing systems are a range of treatments that target the needs of all skin types. Their actions are between that of a cosmeceutical and a medical prescription treatment.


How does pHformula Skin Resurfacing work?

It works by stimulating the production of collagen and new skin cells to deliver fresher, healthier-looking skin while preserving the integrity of your skin’s epidermis. 


What is different about pH Formula?

pHformula has taken skin resurfacing even further and has a unique mechanism of action based on over three decades of combined scientific, medical and skin health knowledge and experience.

A conventional peel uses high concentrations of acids, which cause tissue damage, inflammation, and plenty of peeling.

Ph formula delivers skin resurfacing treatments with no downtime, no peeling and no impact on social interactions.

The pH formula philosophy is about the ‘outside in’ and ‘inside out’ approach. 


The choice of pHformula resurfacing treatments include:

All the above treatments include a combination of different active skin resurfacing serums and a choice of masks to suit your skin condition.


ph formula radiance boost treatment

mela resurfacing treatment

 


Is pHformula Resurfacing Uncomfortable?

Skin resurfacing does not cause pain whilst having treatment. However, when the active ingredients are applied, your skin may feel hot or itchy and a little uncomfortable.  This sensation is normal and does not usually last longer than a few minutes. If you notice pain or become very uncomfortable, it is important that you tell your therapist, who will remove the treatment immediately.


How Many Treatments Will I Need?

The number of treatments needed will depend on your skin concern and the outcome you want to achieve.

A course of between 3 and 6 treatments is typical to achieve the best results.
Our Aesthetician will be able to advise you following your consultation and first treatment, which includes a skin sensitivity test.


Will I Need a Consultation First?

You can book either:

A skin assessment consultation –  a 30-minute consultation to assess and discuss your skin and go over all options. –£25

A pHformula skin assessment, sensitivity test and first treatment- a 60-minute assessment and treatment Offer price on Fresha

The pHformula skin assessment, sensitivity test and first treatment includes:

  • A skin examination and assessment.
  • pHformula SP Complex treatment, which acts as a sensitivity test and a mild resurfacer.
  • A Vitamin C Radiance Boost Treatment,
  • A mask which we can apply in the clinic, or you can take one of our fantastic SOS Sheet Masks to apply that evening at home.
  • We will also give you two sachets of home care to test your skin and start your pHformula skin journey.

We will also recommend a skin regime to prepare your skin to improve your results.


View Our Pre and Post-treatment Advice


View our pHformula Prices


Find out more about pHformula


 

BioRePeel 35% TCA

biorepeel Cheshire

What is BioRePeel?

It is an innovative medical peel, that uses patented 2-phase technology to provides a bio-stimulating, revitalising & peeling-like effect. It is one of the newest peels on the market from CMED AESTHETIC  in Italy.

Its exfoliating and keratolytic action removes the outer corneal skin cell layers to effectively prevent the ageing of the skin, decrease damage from UV light,  as well as decrease pigmentation and acne scars. It also stimulates cell turnover by and stimulating the production of collagen, elastin and hyaluronic acid.

BioRePeelCl3 is multifunctional and is suitable for all ages and all skin types. It has an anti-ageing function that results in brighter, tighter, lighter skin and the reduction of fine lines. It is also suitable for young skin during acute stages of acne, blackheads, with recent mild scaring.


Which areas can the Peel treat?

The peel is effective on the following areas:

  • Face
  • Neck
  • Décolleté
  • Hands
  • Feet
  • Elbows

What are the ingredients of BioRePeel?

The main peel ingredients deliver a level 3 peel and include:

  • TCA 35%
  • Lactobionic acid
  • Salicylic acid
  • Tartaric acid
  • Citric Acid

The results are enhanced with the Biostimulation ingredients including Vitamins C and Revitalisation ingredients including Gamma-aminobutyric acid, Arginine and Riboflavin. The peel is also better-tolerated because of these ingredients.


What is different about BioRePeel?

BioRePeelCl3  is not just a peel it has the following actions:

  • Protective and stabilising actions;
  • Regenerating action
  • Moisturising action
  • Biostimulating action
  • Revitalising action
  • Peeling and keratolytic actions
  • Anti-wrinkle and antioxidant actions
  • Anti-acne, comedones & enlarged pores

biorepeel Cheshire


Whats is the downtime?

There is no downtime, even though the peel contains 35% TCA!

The treatment is quick and delivers instant results with no frosting effect and no visible traces of the procedure.

After treatment, the skin feels soft, refreshed and revitalised.


How often should I have the Peel?

For best results, we recommend a treatment every 7-10 days for 3 to 6 sessions.

You can also combine the BioRePeel with the following treatments:


How do I book a peel?

Arrange a consultation and patch test. This will take about 20 mins we can then get you booked in 48 hours later.

You do not need to prepare your skin for the treatment although you will get better results if you use AHAs and or retinol for a few weeks before your treatment.

We recommend you stop all AHA’s, BHAs and retinol products for 3 days before and 3 days after the peel.

Book your BioRePeel consultation here

Book your consultation here if you prefer a Skin Rejuvenation consultation to go over all treatment options.


View our BioRePeel Prices


View our First BioRePeel Review

BioRepeel review Cheshire